Tumours were diagnosed according to the World Health Organization classification of tumours of the pancreas of domestic animals. This retrospective study analysed formalin-fixed samples of pancreatic carcinomas from 22 dogs, obtained during elective exploratory surgery (n = 16) or if the dog was humanely destroyed (n = 6). The literature on clinically and pathologically characterized canine exocrine pancreatic tumours is limited to 76 cases reported since 1963. Pancreatic carcinomas are rare in dogs and clinical signs are mostly non-specific. Quelle: Journal of comparative pathology 2019. In the course of pancreatitis, a release of Vitamin A and E into the blood stream due to necrotic processes of tissue may be discussed in this speciesĬharacterization of 22 canine pancreatic carcinomas and review of literatureĪutor: Aupperle-Lellbach H, Törner K, Staudacher E, Müller E, Steiger K, Klopfleisch R This study suggests that dogs with pancreatitis have a different metabolism of Vitamin A and E compared to dogs with other diseases and humans with pancreatitis. The study dogs also had significantly higher (P < 0.001) serum Vitamin E levels (average: 36.0 μg/L, range: 15.3-83.7 μg/L) than the control group (average: 20.4 μg/L, range: 1,9-54.6 μg/L). Serum Vitamin A and E levels were measured by HPLC from cooled serum within 72 hours of sampling.ĭogs with pancreatitis had significantly higher (P < 0.001) levels of serum Vitamin A (average 1701 μg/L, range: 405-4448 μg/L) than dogs of the control group (average: 978 μg/L, range: 139 μg/L - 1904 μg/L). The 45 dogs of the control group had serum pancreatic lipase values <40 μg/l and had clinical symptoms concurrent with other diseases than pancreatitis.
Additionally, in 3 dogs pancreatitis was diagnosed by histology of pancreatic tissue biopsies. These dogs all had serum pancreatic lipase concentrations >600 μg/L and clinical symptoms of pancreatitis like vomiting, abdominal pain or inappetence and had received no medical treatment so far. The aim of this retrospective study was to evaluate the level of serum vitamin A and E from routine diagnostic left-over samples in dogs with pancreatitis compared to a control group of dogs with other diseases.Ĥ0 dogs with pancreatitis were included in this study. To our knowledge no studies about Vitamin A and E levels in serum of dogs with pancreatitis have been performed so far. Quelle: ECVIM-CA, 19.– in Mailand, Italien, Congress abstracts, 391.Īcute and chronic pancreatitis in humans results in significantly lower levels of serum Vitamin A and Vitamin E due to antioxidative stress and as part of the inflammatory response.
Serum Vitamin A and E concentrations in dogs with pancreatitisĪutor: Weiß M, Törner K, Grassinger J, Müller E, Aupperle-Lellbach H
0 kommentar(er)
